​The Effects of two Weeks Exhaustive swimming and Curcumin Supplementation on Liver Damage Biomarkers Caused by Alcohol Consumption in Male Wistar Rats

Background: Curcumin is an active ingredient in turmeric, which is used as herbal medicine for the treatment of certain diseases. The aim of this study was to investigate the effects of two weeks of exhaustive swimming and supplementation of curcumin on alcohol induced liver damage biomarkers in male wistar rats. Materials and Methods: In this study, 32 male wistar rats were randomly selected and divided into 4 equal groups: control, training, supplemental curcumin, and training with curcumin supplement. At first, every 8 hours for 4 days, alcohol was gavaged to all groups, proportional to the body weight of each rat. This was followed by an alcohol withdrawal period. After that, the practice period began, including long-term swimming in water, for the exercise group, and the curcumin supplement with exercise group. Finally, blood samples were taken from the heart under anaesthetic Results: Curcumin had no significant effect on AST (P = 0.401) and ALT (P = 0.978) and the ratio of these two enzymes (p = 0.657). Exercise significantly reduced AST (P = 0.022), but did not significantly decrease ALT (P = 0.759) or the ratio of these two enzymes (p = 0.225). Exercise and supplementation interaction did not significantly decrease ALT (P = 0.462) or AST (P = 0.073) activity or the AST / ALT ratio (P = 0.520). Conclusion: The reduction of liver damage markers in this study suggests that exercise and curcumin consumption may, through protective effects, improve the negative effects of alcohol on the liver, and prevent alcohol induced liver disease.